10 April 2017

APPROACH reseacher publishes high impact review on metabolism in osteoarthritis

Recent research suggests that metabolic pathways play an important role in osteoarthritis (OA), and key metabolic pathways and mediators might be targets of future therapies for OA. This is the conclusion of a review published last week in Nature Revieuws Rheumatology, authored by APPROACH researcher Ali Mobasheri.

Immunometabolism is an emerging field at the historically distinct interface between the disciplines of immunology and metabolism. It focuses on the changes in intracellular metabolic pathways in immune cells and how these alterations can modulate their function. The review discusses recent research, suggesting that immunometabolic changes occur in a number of arthritic and rheumatic diseases including OA. Optimal metabolism is important for normal cartilage and synovial joint function but cellular metabolism is drastically altered in OA and aberrant metabolism appears to be a key feature of some phenotypes of OA. In OA, cartillage cells (chondrocytes) undergo fundamental metabolic alterations and gradually shift from a resting regulatory state to a highly metabolically active state. The pathways and mediators that are involved in this metabolic transformation may be targets of future therapies for OA.

The article, entitled "The role of metabolism in the pathogenesis of osteoarthritis", was published on 6 April 2017 in Nature Reviews Rheumatology and can be downloaded here.